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This is how the simulated moving-bed chromatographic separation system
works.
However, the weak point of the simulated moving-bed method is that it
can only perform a separation resulting in two fractions.
As can be seen in Fig. 4, with the simulated moving-bed device, there
is always either components A or component C present in the area between
the feed mixture introduction opening, F, and each opening for the arawal
of components A and C respectively.
Therefore, even if there existed in the feed mixture a component B, having
a migration rate in between that of components A and C, and it collected
in the vicinity of the feed mixture introduction point F, it would be impossible
to extract this component B in a highly purified state, since it would only
exist in a mixed form with either component A and C.
Consequently, by a simulated moving-bed system, unless the position of
elution of the component targeted for extraction was either the fastest
or the slowest among the separated components it was impossible to extract
the component by a single separation operation.
In cases where a targeted component is eluted in a narrow position in
between two impurities or other components, you either had to carry out
the separation operation twice, or link two devices in series.
Owing to this fundamental principle, the use of the simulated moving-bed
system has been limited to 2 fractions. However, naturally there are many
circumstances when the object of separation exists in a multiple component
form. A system which could maintain the high efficiency of the simulated
moving-bed mode and perform separations into three or more product divisions
in a single step had long been awaited.
It was here that through the organic combination of the strengths of
the fixed-bed method adapted for the separation of multicomponent mixtures,
and the simulated moving-bed mode which enables high purity, high concentration,
and high recovery separation, a complete multicomponent separation system,
the New JO Chromatographic Separation Device,
was developed . |